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Safety evaluation: The safety of the cream is assessed through acute toxicity tests, long-term toxicity tests, etc., to ensure that it has no toxic or side effects

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Preclinical signals regarding potential effects on thyroid C-cells (observed with GLP-1 agonists as a class), as well as theoretical questions about bone metabolism and cardiovascular function, are being monitored in ongoing trials

Other conditions such as intestinal overgrowth (known as SIBO), which is also incredibly common among hypothyroid patients (2), can reduce B12 absorption in the GI tract

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