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Acamprosate takes about 5 to 7 days to begin reducing alcohol cravings, with full therapeutic effects developing over several weeks of continuous use

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[DOI] [PubMed] [Google Scholar] 95.Menn-Josephy H., Lee C.S., Nolin A., Christov M., Rybin D.V., Weinberg J.M., Henderson J., Bonegio R., Havasi A

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The pertinent parameter should be the responsivity of the HPA axis network, as revealed by the magnitude of the cortisol awakening response, or the response to an evoked stress