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SCFAs activate GPCRs (GPR43/41) and inhibit histone deacetylases (HDAC), promoting regulatory T-cell (Treg) differentiation while suppressing Th17 cell polarization within the joint, thereby restoring immune homeostasis and reducing pro-inflammatory cytokine release

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Known as the Black Death, bubonic plague killed millions of people in Europe during a series of outbreaks during the Middle Ages

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[Abstract]2026 Apr 15;18(14):20279-20290

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