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As new skin cells generated under better antioxidant protection gradually replace older, damaged cells (a cycle that takes roughly 28-40 days), the cumulative effect becomes visible

The CV solution was aspirated, and the samples were washed with double-distilled water (H 2 O dd )

The main culprits include: Ultraviolet and visible light exposure the strongest daily stimulator Hormonal fluctuations (pregnancy, contraceptives, thyroid changes) Inflammation from acne, eczema or injury (post-inflammatory hyperpigmentation) Ageing and genetics Certain medications or skin trauma Globally, pigmentary disorders affect a significant portion of the population, with surveys showing around half of adults reporting at least one pigmentation concern

Florentin M, Elisaf MS, Rizos CV, et al

There was no significant difference in the number of fetal rats among all groups