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Metabolic parametersincluding insulin resistance, lipid profiles, and gut microbiome alterationsplay a significant role in NAFLD pathogenesis and could provide a broader understanding of GSHs systemic effects

Absorption Challenges Both supplements face absorption issues

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The resulting glutamate overstimulation of NMDA and metabotropic glutamate receptors (mGluRs) further complicates the situation, whereby mGluR activation via phospholipase C (PLC) and inositol trisphosphate (IP 3 ) signaling prompts Ca 2+ overload [138]

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