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Limitations of Current Evidence Several critical limitations characterize the current evidence base for these peptide therapeutics

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History and Development The first GLP-1 agonist, exenatide (Byetta), was approved by the U.S

doi: 10.1016/j.cmet.2018.06.001 53 HuangSC-CEvertsBIvanovaYOSullivanDNascimentoMSmithAMet al

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Unfortunately, levels naturally decline with age, illness, and environmental exposure