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The double-blind multicenter phase 3 trials STEP 1, 3, 4, 5 were conducted in adults (mean age 46.247.3 years), mostly females, with obesity or overweight with 1 weight-related complication (mean BMI 37.838.4 kg/m 2 ) and aimed to demonstrate the superiority of semaglutide 2.4 mg over placebo in BW lowering at 68 or 104 24 weeks as an adjunct to diet and physical activity 23

3-12 months) does not influence food consumption, body weight or mean life span of mice

cDNA was amplified using a real-time PCR machine (QuantStudio, Thermo Fisher Scientific) with primers shown in Table S9

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