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This disruption allows toxic substances and peripheral inflammatory mediators to enter the brain, triggering neuroinflammation

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Signal Transduct Target Ther 9(1):17 Tariot PN, Cummings JL, Katz IR, Mintzer J, Perdomo CA, Schwam EM, Whalen E (2001) A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimers disease in the nursing home setting

In case of the Southern Europe species, creatine was used as a feed supplement aiming to target the expression of the major fish allergen and modulate these species allergenicity

doi: 10.1111/jpn.13725 109 WilliamsERumseyRPowersH

Indeed, chronic ROS can cause protein oxidation of methionine and cysteine residues 112,113 , which in the absence of GSH becomes permanent and might decrease irreversibly CI and CII functionality