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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

Treatment with methylcobalamin or hydroxocobalamin may unmask this condition

This prevents condensation when the seal opens

Shari has worked in healthcare since 1996 and her expertise lies in acute care bedside nursing on a medical oncology floor

Most healthy adults have a heavy store (up to several years worth) of B12 in their liver