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[2] Exposure to nitrous oxide (including recreational use) can cause functional B12 deficiency and worsen neurological manifestations

Option (Evidence Strength: Grades C, C, and B) DMSO (Evidence Strength: Grade C) Two randomized crossover trials reported on the efficacy of intravesical DSMO for IC/BPS patients

Mixing technique: Add BAC water slowly along the vial wall

During the microdose phase (sub-2.5 mg doses), do not expect significant weight change

Surveillance should comprise routine clinical and specific reproductive-related laboratory monitoring, with defined strategies for treatment cessation if issues emerge

Solution should be clear