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Contact urticaria during topical immunotherapy

In human splenocyte cultures, IL-2 levels rose significantly within just five hours of exposure [17]

This gastric stability is what makes oral administration a viable option though "viable" does not mean "equivalent to injection." Bioavailability: Oral vs

No significant difference was achieved in patients who received partial HBOT (2.40.4 pre- compared to 2.20.4 post-HBOT, p = 0.15) and in patients who did not receive HBOT (2.30.5 pre- compared to 2.30.5 post-HBOT, p = 0.85)

doi: 10.1007/s10072-015-2245-7 21 WolfovaK.KuceraM.CermakovaP

Though not usually life-threatening, these skin toxicities can be distressing and lead to dose interruptions or discontinuation