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The importance of the active transport role in metformin elimination has been supported by studies in the OCT1/OCT2-knockout mice, where the observed clearance decreased to approximately the unbound glomerular filtration rate [47]

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29 The antidepressant duloxetine (Cymbalta) has been shown to improve chronic low back pain compared with placebo, but the studies did not include lumbar spinal stenosis

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