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Copper is an endogenous modulator of neural circuit spontaneous activity

As an important hydrolytic enzyme of ceramides [25], increased Acer2 promotes the hydrolytic metabolism of ceramides, which is an important reason for the significantly decreased ceramide levels observed after hypoxic treatment

196 When tumor cells metastasize to distant sites through the circulatory system, they are exposed to severe stress within the blood vessels, such as hemodynamic shear forces and attacks of the immune system

Treatment is always planned after understanding the root cause

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ABC multidrug transporters: structure, function and role in chemoresistance