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The solid components of the brain are 60% fat according to clinical research published in the Taiwanese Journal of Neurology

Concretely, lactylation of PDHA1 at K336 and CPT2 at K457/8 results in the inactivation of both enzymes and the inhibition of OXPHOS by restricting acetyl-CoA influx from pyruvate and fatty acid oxidation, respectively

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"L-carnitine and type 2 diabetes: meta-analysis." Exp Clin Endocrinol Diabetes 2013;121:5

However, AARS is an exception, which relies on lactate-AMP as an intermediate to directly transfer lactyl group to the lysine residues of target proteins with the assistance of ATP [25, 26] As the most well-studied writer, p300-catalyzed lactylation mainly promotes gene transcription [28,29,30,31,32,33,34,35,36,37,38,39] and maintains normal protein structure and functions [40,41,42,43,44,45]

J Biomed Sci 24(1):78