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Distributed under the brand names Geref and Geref Diagnostic, it gained FDA approval in 1997 as a treatment for growth hormone deficiency but was discontinued in 2008 not out of concern for safety or lack of efficacy, but because of manufacturing difficulties.2 3 Yet it remains available in compounded form with a prescription from a licensed healthcare provider
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Milk basic protein increases alveolar bone formation in rat experimental periodontitis
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The compound also appears to interact with the growth hormone receptor signaling cascade, with data from rodent models suggesting upregulation of GH receptor expression in injured tissues, potentially linking BPC-157 activity to IGF-1-mediated tissue maintenance pathways under experimental conditions
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