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In addition to the proteolytic processing by secretases, APP and its corresponding C-terminal fragments are also metabolized by lysosomal proteases

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doi: 10.1016/j.redox.2019.101255 379 WeinbergSESenaLAChandelNS

It has been shown to reduce the activation of the MAPK/ERK and PI3K/Akt pathways, upregulate the cyclin-dependent kinase inhibitor p21, and trigger mitochondrial apoptosis by downregulating the anti-apoptotic proteins Bcl-2/Bcl-xL ( 3.1.4 Polyphenols: precision miRNA targeting for cancer suppression Curcumin emerges as a potent miRNA modulator with specific targeting of oncogenic and tumor suppressor miRNAs

Med 2012, 745483