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These cells integrate into the ovarian tissue, modulating the expression of essential cellular markers by significantly increasing epithelial markers (cytokeratin 7) and estrogen receptors (ER), while concurrently decreasing mesenchymal markers (fibronectin and vimentin), thus reversing the ovarian fibrosis associated with POF

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[117] The following table summarizes the applicant's assertions regarding the substantial clinical improvement criterion

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