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In contrast, chronic excessive inflammation or tissue injury represents another potential consequence of trained immunity, contributing to the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease
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Other measures include: Frequent emollients to improve dryness and symptoms Topical steroids to reduce inflammation and itching Oral antihistamines for symptomatic relief of urticaria Systemic steroids for drug hypersensitivity syndrome Consideration of ciclosporin or intravenous immunoglobulins for SJS/TEN, though there is limited evidence for these measures
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