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More than 80 affected targets have been identified, including those resulting from NO-system blockade as well as those from NO-system overactivity (for a review, see [11,29])

Bessems JG, Loizou G, Krishnan K et al (2014) PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment

[23] The Werner (WRN) DNA helicase gene, which controls the transcription of the crucial NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1, is the source of WS

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