In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration
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11 Lower glutathione levels have also been linked to worse outcomes in infections, including HIV and influenza, likely due to impaired immune cell activity and heightened oxidative stress
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Antioxidant support: Glutathione powder is a powerful antioxidant that helps protect cells from oxidative stress and damage
doi: 10.1016/j.metabol.2021.154708