The method of any one of embodiments 39-59, wherein the composition is free or substantially free of water, C1-C6 alcohols or C1-C6 glycols, C1-C4 alcohols or C1-C4 glycols, or any combination thereof
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Large-scale controlled human trials are not available
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Continuous use makes sense for users still experiencing ongoing improvements without plateau suggesting continued benefit from sustained application, highly satisfied with current results wanting to maintain peak benefits without decline risk, financially comfortable with indefinite product investment as skincare priority, psychologically comfortable with long-term commitment to effective treatment, experiencing rapid benefit decline during previous break attempts indicating necessity of ongoing application, and prioritizing maximum results over cost optimization or flexibility concerns