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Existe racional biolgico e experimentao pr clnica, mas no evidncia clnica ortopdica suficiente para apoiar uso disseminado

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Pharmaceutics 12 (3), 203

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Pineal Gland Signaling and Melatonin Rhythm Modulation The AEDG sequence was originally derived from epithalamin, a polypeptide extract of the bovine pineal gland, and a significant body of research has investigated its interactions with pineal function specifically melatonin synthesis and circadian rhythm regulation