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The Journal of Clinical and Aesthetic Dermatology, January 2017, pages 37-46 5

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The classical example of this was the recognition that an APAP overdose in the mouse causes the formation of a reactive metabolite, which first depletes glutathione (GSH) and then binds to sulfhydryl groups of proteins triggering cell death [79]

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Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

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doi: 10.3390/ijms231911899

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doi: 10.1038/s41392-020-00428-9 11 CrielaardBJLammersTRivellaS

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