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Further supporting melatonins potential impact on brain insulin, a rat study demonstrated that melatonin, upon binding to its membrane-bound receptors, can initiate intracellular pathways in the brain typically activated by insulin binding to the insulin receptor (e.g., AKT serine phosphorylation) [137]

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Further, the difference in the accumulation profile was analyzed across a range of physicochemical parameters, including hydrogen bonding numbers, rotatable bonds, molecular weight, topological polar surface area, ClogP, and logS (Fig

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