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Though human evidence is preliminary, these findings hint at uses beyond musculoskeletal repair

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Cancer 15 , 608624 (2015)

In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]