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doi: 10.1016/j.chembiol.2010.12.022

For example, the review mentioned one study suggesting creatine may increase manic or hypomanic episodes in people with bipolar disorder and another linking just a week of 25 grams (g) daily supplements to increased nervousness and aggression in 2 out of 10 study participants

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doi:10.1016/j.jtauto.2021.100131