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Exclusive use of folic acid in treating vitamin B12 deficient megaloblastic anemia could result in progressive and irreversible neurologic damage
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In addition to the lean and ob/ob mice, the study included 3-KO mice and WT controls obtained from genetically verified breeding colonies
Only an estimated 1%2% of oral B12 can be passively absorbed and therefore, high dosages of oral B12 are required to provide therapeutic benefit in cases where the receptor-mediated process malfunctions ( FIGURE 1 In the receptor-mediated absorptive process, ingested B12 is initially bound to Haptocorrin (HC)/R-factor secreted by salivary glands
This finding is encouraging, as it suggests 5-Amino-1MQ works by altering metabolic function rather than suppressing hunger
