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The limited volume that the nasal cavity can accommodate, approximately 100-200 microliters per nostril without runoff, means that higher concentrations deliver more peptide per spray

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The selectivity arises from the peptides structure representing only the lipolytic region of growth hormone without the receptor-binding domains responsible for broader effects

This pleiotropic profile is part of what makes it difficult to model in humans: the compound does not have a single clean pharmacological target

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