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Presynaptic cytoplasmic Ca 2+ can be depleted by several complementary mechanisms, including sarcoendoplasmic reticulum Ca 2+ -ATPase (SERCA) to the endoplasmic reticulum (ER), plasma membrane Ca 2+ -ATPase to the extracellular space, and MCU to the mitochondrial matrix [51,52,53]

Differential Effects of Itaconate and Its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes. Neurochemical Research 50: 24

The condition affects over 14 million Americans and approximately 400 million people worldwide, yet many cases go undiagnosed because people assume they simply have sensitive skin

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