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In this coordinated system, GSH provides rapid copper sequestration and distribution capacity, whereas certain MTs serve as high-affinity copper reservoirs that limit metal toxicity

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Future trials should enrich truly deficient, higher-risk phenotypes, standardize regimens, and prioritize event-driven hard endpoints with embedded mechanistic markers to confirm on-target biology

doi: 10.18632/oncotarget.15704 223 DeanJPSprengerCCWanJHaugkKEllisWJLinDWet al

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine

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