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For instance, early-onset pneumonia in calves showed increased total bacterial load and decreased -diversity by day 3 after birth, suggesting that BRD arose from opportunistic pathogen overgrowth under dysbiotic conditions 104,105

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It has also been shown that bilirubin treatment reduced p-p65, p-IB, and IB protein levels to normal levels, suggesting that bilirubin specifically reduces NF-B pathway activation associated with inflammation

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