J Clin Invest 2015;125:1591-602
4 Metabolic interactions in the hepatocellular carcinoma tumor microenvironment 4.1 Metabolic crosstalk between hepatic stellate cells and hepatocellular carcinoma cells Cancer cells maintain an alkaline intracellular environment by undergoing aerobic glycolysis, which generates a large amount of protons that are transported to the extracellular space through upregulation of H+ transport proteins
This is the reason why most practitioners who recommend L-Carnitine recommend that their clients use a supplemental form instead of attempting to ingest enough merely from food
Cystinosin deficiency leads to impaired lysosomal clearance and disrupted endolysosomal trafficking, which in turn contributes to defective autophagy and altered proteostasis [144, 146, 147]
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