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Biochem J 329:231241

The principal metabolite of caffeine is paraxanthine [53]

[DOI] [PMC free article] [PubMed] [Google Scholar] 1155.Maamar M., Artime A., Pariente E., Fierro P., Ruiz Y., Gutirrez S., Tobalina M., Daz-Salazar S., Ramos C., Olmos J.M., et al

Stroma-activated integrin-linked kinase (ILK) supports survival of leukemic cells via stimulation of Notch-Hes signaling: new therapeutic opportunities

These factors regulate autophagy through transcription-dependent and transcription-independent mechanisms by modulating the expression of ATGs (such as ULK1, BECN1, LC3 , and ATG7 ) and lysosomal components, as well as influencing upstream signaling pathways such as the mTOR, AMPK, and PI3K-AKT pathways

J Cardiol 1991;21(2):493-504