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This decreases the amount of active agent which are lost and correspondingly increases the amount delivered to the subject

We confirmed the integration of BHB in TCA cycle intermediates and bioenergetic amino acids in CD4 + T cells in IAV-infected mice in vivo and ex vivo (Extended Data Fig

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The ability of mTORC1 to sense the presence of amino acids and regulate protein translation ensures that cell metabolism is intimately coordinated with the macronutrient

However, after a large dose of APAP, the sulfonation reaction becomes saturated and the build-up of NAPQI depletes GSH in the liver, causing further accumulation of NAPQI