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In animal studies, this change inhibits detoxification, depletes glutathione levels, and increases inflammation

OH reacts with purine and pyrimidine bases in DNA and RNA ( OH attacks thymine or deoxyguanosine bases to generate 5-hydroxy-6-hydrothymine or 8-hydroxy-2'-deoxyguanosine (8-OHdG)

Kt hp glutathione vi kem chng nng, n ung lnh mnh v chm sc da c bn s gip tng kh nng duy tr ln da khe, ti v u mu

Molecular basis of vitamin E action: tocotrienol-potent inhibitor of inducible expression of inflammatory microRNA

Mechanism of Action Glutathione is an essential molecule required for detoxification

In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL)