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7 Symptoms of DKA include 7 : Fruity smelling breath Dry or flushed skin Nausea or vomiting Stomach pain Trouble breathing Trouble paying attention or feeling confused An episode of DKA early in the disease can lead to 8 : More DKA events Severe low blood sugar A greater risk of death Longer hospital stays Higher levels of insulin required over time A shorter remission period (called a honeymoon period during which the pancreas still makes some insulin) Worse control of blood sugar over time All of this increases the risk of diabetes-related complications such as heart disease, kidney disease, and eye diseases

478 Two phase III clinical trials (NCT01931566 and NCT02284906) assessed the safety and efficacy of the drug in participants with AD-induced MCI but were terminated due to insufficient efficacy

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doi: 10.1016/j.mce.2020.111097 131 LuiDTWLeeCHChowWSLeeACHTamARFongCHYet al