Intratympanic injectionEach animal was positioned so that the head was tilted at an angle to favor injection towards the round window niche
The project, developed by CmTo in collaboration with DIST-Politecnico di Torino, ISPRA, CREA, and CSI Piemonte (Giaimo & Barbieri, 2018
One product is approved with post-marketing data
Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma
Metallothioneins are neuroprotective agents in lysosomal storage disorders
Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem