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Its HDAC inhibitory activity directly contributes to the reactivation of silenced tumor suppressor genes and is a key mechanism underlying its remarkable anti-tumor effects in urologic and other cancers, as observed both in vitro and in vivo without significant toxicity (64)

Dose-dependent accumulation of glucose in the intestinal wall and lumen induced by metformin as revealed by 18 F-labelled fluorodeoxyglucose positron emission tomography-MRI

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A 0.2mL dose converts to 0.2 100 = 20 units

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Accordingly, there is an urgent need to discover ferroptosis-inducing drugs for the treatment of cancers, especially drug-resistant cancers