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The degree of vascular permeability, the density and composition of the extracellular matrix and the balance of immune cell subsets differ across tumor types, among patients with the same diagnosis and between individual lesions in one patient [115]

36 studies were included (35 preclinical [rodents] studies, 1 clinical [humans] study)

In general, it is assumed that the two main limiting factors are the levels of cysteine and of the enzyme gamma-glutamyl-cysteine synthetase (also known as glutamate-cysteine ligase)

doi: 10.1002/mnfr.202300051 234 DrydenGWLamABeattyKQazzazHHMcClainCJ

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