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Furthermore, the reduction in bioavailable copper impairs the function of copper-dependent proteins and signaling pathways, including SOD1, copper chaperones (ATOX1, ATP7A), and transcription factors, such as HIF-1 and NF-B [221]

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Obese men have higher estrogen levels, increasing gynecomastia risk

IN delivery provides a sustained, lower-level exposure over 8 weeks

Some individuals report transient headache or flushing

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