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Group three received NAC, and Group four received MET + NAC

TF: Methodology, Writing original draft, Writing review & editing

While tirzepatide slows gastric emptying and reduces caloric intake through incretin receptor activation, 5-amino-1MQ works intracellularly to inhibit nicotinamide N-methyltransferase (NNMT), shifting cellular metabolism toward fat oxidation independent of appetite suppression

The Pei 2024 meta-analysis has a larger total patient pool (1,458 vs 472), giving it more overall statistical power

The endogenous GSH could trigger the release of NO and active Pt (II) from SPNA simultaneously (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )

Following fixation in 4% paraformaldehyde (PFA), 5 dpf Brn3c:mGFP larvae, which express membrane-bound GFP in hair cells, were rinsed twice with phosphate-buffered saline (PBS) for 10 min each and then once with dH 2 o for 20 min