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As tirzepatide promotes substantial weight reductionclinical trials such as SURMOUNT-1 demonstrated average weight loss of approximately 20.9% of body weight at the 15 mg dose in adults without diabetesthis metabolic shift can influence the hypothalamic-pituitary-ovarian axis that regulates menstruation
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Infusion of obese Zucker rats as well as lean littermates with AICAR decreases plasma TAG and FA concentrations, as well as glycerol turnover (37), whereas mice lacking the AMPK-alpha2 subunit have been shown to have increased adiposity and weight gain (98, 131)
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