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As a result, GPX4 and GSH levels were markedly reduced, accompanied by elevated ROS levels and increased lipid peroxidation, collectively driving ferroptosis in cortical neurons and leading to neurodegeneration

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Consistent with the involvement of MORF2 in RS 66 , our results showed that overexpression of GmMORF2a or SsCm1 alleviates the down-regulation of immunization-induced RS marker gene LHCB1.2 (Fig