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This study demonstrates that p53-specific effects of APR-246 are only observable in a narrow dosing window, under a specific set of conditions

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Importantly, following 48 h of treatment with TGF1 or GHK on lung fibroblasts from former smokers with COPD, we were able to restore this intrinsic defect, which we propose is through organization of the actin cytoskeleton to a contractile phenotype as demonstrated by the confocal images displayed in Figure 6a

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