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Systematic reviews suggest that acupuncture modulates neurotrophic factors (e.g., BDNF), neurotransmitters (e.g., 5-HT, dopamine), inflammatory cytokines, and the neuroendocrine system, exerting both antidepressant and anticonvulsant effects (Huang et al., 2024)

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227 For pain management, case studies, clinical trials and meta-analyses of PEA have demonstrated good evidence of efficacy and excellent tolerability at typical doses of 6001200 mg daily