These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [1]
Bone morphogenetic proteins (BMPs) are the most representative example, which have been granted US Food and Drug Administration (FDA) approval for clinical applications in recalcitrant long bone non-unions, lumbar fusion and open tibial shaft fractures [1618]
Toxicon 40:10171025 Iwasaki Y, Saito Y, Nakano Y, Mochizuki K, Sakata O, Ito R, Saito K, Nakazawa H (2009) Chromatographic and mass spectrometric analysis of glutathione in biological samples
Ogasawara et al., 2007)
While never achieving widespread pharmaceutical approval in North America, DSIP has maintained consistent interest in research circles and among those seeking alternatives to conventional sleep medications
Biochem Biophys Res Commun (2010) 400(4):72933.10.1016/j.bbrc.2010.08.138 42 BernsenPLGabrelsFJRuitenbeekWHamburgerHL
