Usman SS, Dahiru M, Abdullahi B et al
a d , Flow cytometry plots showing the gating strategies used to identify human melanoma cells in the blood ( a ) or lymph ( b ) of NSG mice or mouse melanoma cells in the blood ( c ) or lymph ( d ) of C57BL mice
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226,477 These physiological studies are consistent with a model where riboswitches sense higher bioavailable concentration of Mn II than is sensed by their counterpart protein metalloregulators, and thus likely function as a fail-safe on signal to prevent Mn II toxicity by high cellular Mn II
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PEGylation is the best modification for aptamer stability and half-life circulation in solid tumors with poorly vascularized regions with dense extracellular matrix that leads to slower drug uptake, such as lung, colon, and breast cancer (139)
