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& Ginsburg, H

Interestingly, by comparing ROS expression in both wound healing (early stage, lower levels) and regeneration (later stage, elevated levels) in planarians, Van Huizen et al

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With the occurrence of abnormal glycolipid metabolism, cells activate unfolded proteins in response to misfolded and unfolded protein aggregation and calcium balance in the ER, and misfolded proteins induce ROS generation while OS disturbs the ER redox state, thereby breaking the correct disulfide bond formation and proper protein foldin (Wang J