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In insulin-resistant subjects, ANGPTL3 levels directly correlated with HOMA-IR as well as with glucose and insulin circulating levels ( ANGPTL6 is expressed in different tissues at very low levels but hepatocytes are the major source of its secretion

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(Kato et al., 2022) As the mucins are secreted and insufficiently hydrated, the viscosity and elasticity of the mucus increase and make mucociliary and cough clearance more difficult (Tambascio et al., 2013

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