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Via high-butyrate diet intervention and adoptive transfer experiments, it confirmed that a high-butyrate diet can induce the differentiation of follicular Tregs through HDAC inhibition, suppress the production of type II collagen (CII)-specific autoantibodies, and reduce joint swelling and bone erosion

Kelly FJ

The mechanism likely involves improved mitochondrial function within muscle cells, enhanced stem cell activation, and better recovery capacity

2025 Nov 28;18(12):1822

By identifying the acid and the conjugate acid , and comparing their two pK a values

Affordability will be a struggle for many in the long run, as chronic therapy can be costly and many insurance companies do not cover obesity as a valid reason for treatment